Anita Layton

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  Managing Blood Sugar and Kidney Health
  Anita Layton

  Diabetes has serious impact on the kidney: it elevates solute and water transport along the nephron and induces glomerular hyperfiltration. A new class of diabetes drugs, namely the sodium-glucose co-transporter 2 (SGLT2) inhibitors, enhance glucose excretion and lower hyperglycemia in diabetes. These drugs work by targeting Na+ and glucose reabsorption along the proximal convoluted tubule (a proximal segment of the nephron). The goal of this study is to explore how SGLT2 inhibition affects solute transport and oxygen consumption along the rat nephron in chronic kidney disease, in the presence but also in the absence of diabetes.